BPF has been shown to improve serum lipid profiles, making it beneficial for individuals with high cholesterol or metabolic syndrome. as potent antioxidants, helping to reduce oxidative stress in the body. Some mechanisms are similar to those of some cholesterol-lowering medications. Clinical studies have shown that BPF can improve liver health in patients with NAFLD and metabolic syndrome, others have shown BPF may help normalize blood pressure in individuals with metabolic syndrome.
Bergamot shows improvements in MASLD (Metabolic dysfunction-associated steatotic liver disease), Carresi et al, 2025, Italy. "Our results demonstrated that BPF improved diastolic dysfunction and reduced chronic low-grade inflammation" https://pubmed.ncbi.nlm.nih.gov/40695041/
Bergamont shows improvement in Cholesterol reduction. Daniel A Jacobo-Velázquez, 2025, Mexico. "Beyond medications, dietary interventions and functional foods offer significant cholesterol-lowering potential." https://pubmed.ncbi.nlm.nih.gov/40871675/
Promising results show that key compounds such as bergamot polyphenolic fraction (BPF), cynaropicrin, oleuropein, quercetin, resveratrol, and serotonin can modulate oxidative stress, inflammation, the tumor microenvironment, the cell cycle, and drug resistance. Carmen Altomare, 2025, Italy. https://pubmed.ncbi.nlm.nih.gov/40732979/
The dietary supplement citrulline might increase nitric oxide levels, leading to vasodilation and improved blood flow, potentially benefiting athletes' aerobic exercise performance. "However, rapid oxidative impairment of the L-arginine/nitric oxide (NO) pathway limits these effects. This is countered by Bergamot Polyphenolic Fraction Gold® (BPFG), a strong natural antioxidant." Rocco Mollace, 2025, Italy https://pubmed.ncbi.nlm.nih.gov/40218864/
"These results suggest that bergamot extracts, especially those rich in polyphenols, may be a valuable adjunct in the management of osteosarcopenic obesity and other associated clinical conditions involving pro-inflammatory effects on organs and tissues." Giuseppe Mazzola, 2024, Italy https://pubmed.ncbi.nlm.nih.gov/39517207/
"The results showed the best quality attributes of bergamot fruits harvested in the PDO area. In particular, higher levels of total soluble solids, stable acidity, and higher juice were found. In addition, higher contents of ascorbic and citric acids, which are nutritionally valuable and tasteful, were found. The phenolic profile, characterized by the key compounds of bergamot, highlighted the better nutraceutical potential of the fruit grown in the PDO area. Antonio Gattuso, 2024, Italy https://pubmed.ncbi.nlm.nih.gov/38998585/
"Dramatic Suppression of Lipogenesis and No Increase in Beta-Oxidation Gene Expression Are among the Key Effects of Bergamot Flavonoids in Fatty Liver Disease" Maddalena Parafati, 2024, Italy https://pubmed.ncbi.nlm.nih.gov/39061835/
"Overall, these findings support the use of the tested dietary supplement containing dry extracts of bergamot and artichoke as a safe and effective approach for the prevention and management of a broad spectrum of cardiometabolic disorders." Federica Fogacci, 2024, Italy https://pubmed.ncbi.nlm.nih.gov/38892519/
"A nutraceutical containing bioactive components from bergamot and wild cardoon reduced serum uric acid during 6 weeks in adults with fatty liver." Yvelise Ferro, 2022, Italy. https://pubmed.ncbi.nlm.nih.gov/36556930/
"Early clinical trials along with the mechanistic studies that have been performed suggest that bergamot can reduce total cholesterol and LDL-C through mechanisms that are distinct from current pharmaceutical approaches. Mirielle C Nauman, 2019, USA. https://pmc.ncbi.nlm.nih.gov/articles/PMC6497409/