1. Effects of Collagen Hydrolysates on Human Brain Structure and Cognitive Function: A Pilot Clinical Study This open-label pilot study gave 5 g/day collagen hydrolysate to 30 healthy adults for four weeks. Results showed significant improvements in brain structure (fractional anisotropy) and language cognitive tests (word list memory and verbal paired associate learning). Collagen intake may positively affect brain structure and cognitive function. (PubMed)
2. Effects of a Jellyfish Collagen-Based Amino Acid Supplement on Cognitive Function and Memory: A Pilot Investigation In an eight-week trial of a proprietary jellyfish collagen extract, participants showed statistically significant improvements in composite cognitive scores, including memory and executive function, and faster reaction times. EEG measures and participant reports suggested enhanced alertness, energy, and focus. Results indicate potential cognitive benefits needing further research. (ResearchGate)
3. PubMed 31878021 – Effects of Collagen Hydrolysates on Human Brain Structure and Cognitive Function This published study (PMID 31878021) reports that daily collagen hydrolysate ingestion for four weeks improved brain structural measures and cognitive function in healthy adults. Improvements correlated moderately with memory test changes. The findings support a possible role for collagen in enhancing brain health, though mechanisms and broader effects require further study. (PubMed)
4. Efficacy and Safety of Native Type II Collagen in Knee Osteoarthritis (PMC9780623) A 12-week randomized, double-blind trial showed that low-dose native type II collagen significantly improved joint health, reduced pain, stiffness, and enhanced physical function in knee osteoarthritis compared to placebo. Effects were comparable to glucosamine + chondroitin, with better quality-of-life scores and a good safety profile. (PMC)
5. “Collagen” – Sportärztezeitung Article (sportaerztezeitung.com) This article reviews collagen’s role in joint health, highlighting that undenatured type II collagen improves joint flexibility, cartilage support, and pain relief at low doses. It discusses different collagen types, evidence from clinical studies, and collagen’s therapeutic potential in osteoarthritis and connective tissue function. (sportärztezeitung)
6. Do Collagen Supplements Work? Science-Backed Benefits… (news-medical.net) Oral collagen peptides show clinical benefits for skin, joint, bone, and muscle health. Evidence suggests supplementation improves skin elasticity, hydration, joint function, bone density, and muscle outcomes in adults. Effects are generally modest but statistically significant in randomized controlled trials and meta-analyses. (News-Medical)
7. Collagen for Brain Repair: Therapeutic Perspectives (PMC5950659) This review describes collagen biomaterials as promising tools for central nervous system repair due to biocompatibility and versatility. Collagen scaffolds and microspheres can deliver therapeutic factors, encapsulate cells, support regeneration, and provide structural support in neurodegenerative and injury contexts, offering potential neuroprotective and regenerative strategies. (PMC)
8. A Review of the Effects of Collagen Treatment in Clinical Studies (PMC8620403) This review covers collagen treatments across various clinical contexts, including skin regeneration, bone defects, sarcopenia, wound healing, dental therapy, gastroesophageal reflux, osteoarthritis, and rheumatoid arthritis. Collagen-based therapies generally show beneficial effects and may help manage comorbid conditions linked to collagen deficiency. (PMC)
1: https://pmc.ncbi.nlm.nih.gov/articles/PMC9780623/ " Efficacy and safety of native type II collagen in modulating knee osteoarthritis symptoms: a randomised, double-blind, placebo-controlled trial - PMC "