"Evaluation of the effectiveness of curcumin and piperine co-supplementation on inflammatory factors, cardiac biomarkers, atrial fibrillation, and clinical outcomes after coronary artery bypass graft surgery "
First author: Sahar Dadkhah Tehrani Publication date: Epub May 18, 2024; issue Aug 2024 Year: 2024 Place: Iran
This double-blind, placebo-controlled trial studied 80 adults after bypass surgery. Participants received different doses of curcumin with piperine or placebo for five days. The supplement group showed lower C-reactive protein levels and higher total antioxidant capacity, indicating reduced inflammation and stronger antioxidant defenses during early postoperative recovery. Trial Link: https://pubmed.ncbi.nlm.nih.gov/38901949/
"Curcumin's Effect on Inflammatory Response following Percutaneous Coronary Intervention in Adult Patients with Stable Coronary Heart Disease"
First author: Todung Silalahi Publication date: Epub Jan 29, 2021; Place: Indonesia
This double-blind trial studied 50 patients with stable coronary heart disease undergoing PCI. Participants took curcumin or placebo starting seven days before and continuing after the procedure. Curcumin users showed greater reductions in inflammatory markers over time, suggesting it may soften the body’s inflammatory response to PCI during early recovery.
Trial Link: https://pubmed.ncbi.nlm.nih.gov/34054271/
"Oral glutamine reduces myocardial damage after coronary revascularization under cardiopulmonary bypass: A randomized clinical trial"
Authors: Narcisse, M., et al. Date/Year: March 2025 Place: Multicenter
This randomized trial tested whether taking L-glutamine before bypass surgery could protect the heart. Patients used oral glutamine for three days before their operation. After surgery, heart injury markers like troponin and CK-MB were much lower. Researchers concluded glutamine reduces blood-flow related damage and supports heart recovery after major surgery.
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/28421779/
"Supplementation of L-Alanyl-L-Glutamine and Fish Oil Improves Body Composition and Quality of Life in Patients With Chronic Heart Failure"
Authors: Sanchez-Guzman, M. A., et al. Date/Year: 2020 Place: Columbia University Medical Center, USA
In this double-blind trial, people with stable chronic heart failure received daily L-alanyl-L-glutamine. Exercise capacity rose slightly but not significantly. However, patients gained lean body mass and reported better quality of life. The supplement supported protein metabolism, reduced inflammation, and may help prevent dangerous muscle wasting linked to higher mortality.
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/26269566/